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The Enabling Layer: Why Data, Platforms, and Governance Matter More Than Tools
Decision Architecture Thomas Keller 2/16/26 Decision Architecture Thomas Keller 2/16/26

The Enabling Layer: Why Data, Platforms, and Governance Matter More Than Tools

Pharma R&D faces challenges not due to a lack of science, AI, or data, but because it lacks decision-grade systems. Despite significant investments in AI and multimodal platforms, high portfolio attrition persists because one of the bottleneck is the enabling layer. The structural architecture determining whether a scientific signal translates into successful capital allocation. When this layer is overlooked, AI redistributes uncertainty instead of reducing it, necessitating a focus on designing Evidence Continuity and Escalation Integrity to build truly decision-ready systems.

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Thomas Keller trading as Arête Pharma Coach | Sole trader | United Kingdom

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78 The Crescent, Mandelbrote Drive
Littlemore, Oxford, OX4 4XQ, UK

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Thomas.H.Keller@outlook.com
+44 (0) 7717801806